135729-62-3 Palonosetron Hydrochloride

Appearance White to Off-White Solid
Melting point:>290 degree
alpha D25 -94.1 degree (c=0.4 in water)
storage temp. Inert atmosphere,Store in freezer, under -20 degree

optical activity[ ]/D -90 to -110 degree , c =0.4 in H2O
Water Solubility H2O: 20mg/mL, clear

 

     Palonosetron hydrochloride, chemical name: 2- [1-azabicyclo (2.2.2) oct-3S-yl] -2,3,3aS, 4,5,6-hexahydro-1H-benzo [de] isoquinolin-1-one hydrochloride. It is a second-generation 5-HT3 receptor antagonist Palonosetron is a highly affinity 5-HT3 receptor selective antagonist, with no or low affinity for other receptors. The 5-HT3 receptor is located in the central and peripheral vagus nerve endings of the chemotherapy-induced emetic zone in the medulla oblongata. Chemotherapy drugs stimulate chromaffin cells in the small intestine to release 5-HT, which then activates 5-HT3 receptors in the vagus afferent nerves, leading to vomiting reflex.

 

135729-62-3

(S,S)-Palonosetron Hydrochloride

1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, hydrochloride (1:1), (3aS)-

RS 25259-197

(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one hydrochloride

(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one;hydrochloride

(3aS)-2,3,3a,4,5,6-Hexahydro-2-((3S)-3-quinuclidinyl)-1H-benz(de)isoquinolin-1-one monohydrochloride

(S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride

1H-Benz(de)isoquinolin-1-one, 2-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2,3,3a,4,5,6-hexahydro-, monohydrochloride, (3aS)-

 

 

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